Chống viêm và chống oxi hóa là chìa khóa bảo vệ tim mạch của thuốc SGLT2i và GLP-1A. Các nghiên cứu lâm sàng lớn đều làm giảm MACE.

Chống viêm và chống oxi hóa là chìa khóa bảo vệ tim mạch của thuốc SGLT2i và GLP-1A. Các nghiên cứu lâm sàng lớn đều làm giảm MACE.
Nguồn nội dung & ảnh: Thầy Nguyễn Văn Long – Bộ Môn Nội – TNU.Có thể là hình ảnh về văn bản cho biết 'TABLE Summary the GLP-1 RA and SGLT2-i Cardiovascular Outcome Trials Agent EMPA-REG CANVAS Median follow-up, yrs Mean baseline Primary outcome LEADER 7,020 3.1 8.1 death Canagliflozin 10,142 2.4 8.2 death Liraglutide 9,340 SUSTAIN-6 (95% CI) Nonfatal Nonfatal stroke 0.86 (0.74-0.99), 8.7 death Nonfatal Nonfatal stroke 0.86 (0.75-0.97), 2.1 8.7 death Genital infections (male and female) Nonfatal Nonfatal stroke 0.87 (0.78-0.97) Nonfatal Nonfatal stroke 0.74 (0.58-0.95) Amputations, fractures, Acute gallstone disease, injection Retinopathy, gastrointestinal male genital infections, site reactions, adverse disorders, adverse female mycotic events infections, volume depletion Bolded statistically significant lucagon-like (nausea, vomiting, diarrhea, abdominal pain/discomfort, anorexia) (nausea, A1c;'Có thể là hình ảnh về văn bản cho biết 'SGLT-2i Empagliflozin Canagliflozin Type 2 Diabetes Mellitus GLP-1RA Liraglutide Semaglutide Metformin Statin Hemoglobin A1c >7.0% Heart Failure ASCVD Renal Disease Primary Prevention SGLT-2i SGLT-2i orGLP-1RA or RA SGLT-2i> GLP-1 RA* SGLT-2i GLT- or GLP-1 RA'Có thể là hình ảnh về văn bản cho biết 'SGLT-2 Inhibitors GLP-1R Agonists Preload Afterload Epicardial Fat Satiety Nausea Glycosuria Natriuresis Uricosuria Hemodynamic Effect Major Adverse Cardiovascular Events Nephropathy Weight Blood Pressure Anti-Atherogenic Effect Gastric motility Chylomicrons Vasodiliation Insulin LGlucagon Post-prandial randial Glucose'
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