![Discovery of a Potent and Selective EGFR Inhibitor (AZD9291) of Both Sensitizing and T790M Resistance Mutations That Spares the Wild Type Form of the Receptor](https://www.spandidos-publications.com/article_images/ijo/58/2/IJO-58-02-0171-g00.jpg)
Overall survival in stage IV EGFR mutation‑positive NSCLC: Comparing first‑, second‑ and third‑generation EGFR‑TKIs (Review)
![Discovery of a Potent and Selective EGFR Inhibitor (AZD9291) of Both Sensitizing and T790M Resistance Mutations That Spares the Wild Type Form of the Receptor](https://file.medchemexpress.com/product_pic/hy-79077.gif)
Osimertinib dimesylate (AZD-9291 dimesylate), EGFR Inhibitor
![Discovery of a Potent and Selective EGFR Inhibitor (AZD9291) of Both Sensitizing and T790M Resistance Mutations That Spares the Wild Type Form of the Receptor](https://europepmc.org/articles/PMC4315625/bin/nihms-603421-f0001.jpg)
AZD9291, an irreversible EGFR TKI, overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer. - Abstract - Europe PMC
![Discovery of a Potent and Selective EGFR Inhibitor (AZD9291) of Both Sensitizing and T790M Resistance Mutations That Spares the Wild Type Form of the Receptor](https://pubs.acs.org/cms/10.1021/jm500973a/asset/images/large/jm-2014-00973a_0022.jpeg)
Discovery of a Potent and Selective EGFR Inhibitor (AZD9291) of Both Sensitizing and T790M Resistance Mutations That Spares the Wild Type Form of the Receptor
![Discovery of a Potent and Selective EGFR Inhibitor (AZD9291) of Both Sensitizing and T790M Resistance Mutations That Spares the Wild Type Form of the Receptor](https://media.springernature.com/lw685/springer-static/image/art%3A10.1007%2Fs00044-022-02952-5/MediaObjects/44_2022_2952_Fig1_HTML.png)
Discovery of mobocertinib, a new irreversible tyrosine kinase inhibitor indicated for the treatment of non-small-cell lung cancer harboring EGFR exon 20 insertion mutations
![Discovery of a Potent and Selective EGFR Inhibitor (AZD9291) of Both Sensitizing and T790M Resistance Mutations That Spares the Wild Type Form of the Receptor](https://pubs.acs.org/cms/10.1021/jm500973a/asset/images/medium/jm-2014-00973a_0029.gif)
Discovery of a Potent and Selective EGFR Inhibitor (AZD9291) of Both Sensitizing and T790M Resistance Mutations That Spares the Wild Type Form of the Receptor
![Discovery of a Potent and Selective EGFR Inhibitor (AZD9291) of Both Sensitizing and T790M Resistance Mutations That Spares the Wild Type Form of the Receptor](https://i1.rgstatic.net/publication/274965395_Acquired_Resistance_to_the_Mutant-Selective_EGFR_Inhibitor_AZD9291_Is_Associated_with_Increased_Dependence_on_RAS_Signaling_in_Preclinical_Models/links/5836ec8708ae503ddbb551ca/largepreview.png)
PDF) Acquired Resistance to the Mutant-Selective EGFR Inhibitor AZD9291 Is Associated with Increased Dependence on RAS Signaling in Preclinical Models
![Discovery of a Potent and Selective EGFR Inhibitor (AZD9291) of Both Sensitizing and T790M Resistance Mutations That Spares the Wild Type Form of the Receptor](https://media.springernature.com/lw685/springer-static/image/art%3A10.1007%2Fs00044-022-02952-5/MediaObjects/44_2022_2952_Fig7_HTML.png)
Discovery of mobocertinib, a new irreversible tyrosine kinase inhibitor indicated for the treatment of non-small-cell lung cancer harboring EGFR exon 20 insertion mutations
![Discovery of a Potent and Selective EGFR Inhibitor (AZD9291) of Both Sensitizing and T790M Resistance Mutations That Spares the Wild Type Form of the Receptor](https://pubs.acs.org/cms/10.1021/jm500973a/asset/images/medium/jm-2014-00973a_0002.gif)
Discovery of a Potent and Selective EGFR Inhibitor (AZD9291) of Both Sensitizing and T790M Resistance Mutations That Spares the Wild Type Form of the Receptor
![Discovery of a Potent and Selective EGFR Inhibitor (AZD9291) of Both Sensitizing and T790M Resistance Mutations That Spares the Wild Type Form of the Receptor](https://pubs.acs.org/cms/10.1021/jm500973a/asset/images/large/jm-2014-00973a_0003.jpeg)
Discovery of a Potent and Selective EGFR Inhibitor (AZD9291) of Both Sensitizing and T790M Resistance Mutations That Spares the Wild Type Form of the Receptor
![Discovery of a Potent and Selective EGFR Inhibitor (AZD9291) of Both Sensitizing and T790M Resistance Mutations That Spares the Wild Type Form of the Receptor](https://d3i71xaburhd42.cloudfront.net/54ed5ab44c0414bd1553f438c34a68224554ff0e/4-Figure3-1.png)
PDF] Novel Selective and Potent EGFR Inhibitor that Overcomes T790M-Mediated Resistance in Non-Small Cell Lung Cancer
![Discovery of a Potent and Selective EGFR Inhibitor (AZD9291) of Both Sensitizing and T790M Resistance Mutations That Spares the Wild Type Form of the Receptor](https://pubs.acs.org/cms/10.1021/jm500973a/asset/images/large/jm-2014-00973a_0019.jpeg)
Discovery of a Potent and Selective EGFR Inhibitor (AZD9291) of Both Sensitizing and T790M Resistance Mutations That Spares the Wild Type Form of the Receptor
![Discovery of a Potent and Selective EGFR Inhibitor (AZD9291) of Both Sensitizing and T790M Resistance Mutations That Spares the Wild Type Form of the Receptor](https://pubs.acs.org/cms/10.1021/jm500973a/asset/images/medium/jm-2014-00973a_0014.gif)
Discovery of a Potent and Selective EGFR Inhibitor (AZD9291) of Both Sensitizing and T790M Resistance Mutations That Spares the Wild Type Form of the Receptor
![Discovery of a Potent and Selective EGFR Inhibitor (AZD9291) of Both Sensitizing and T790M Resistance Mutations That Spares the Wild Type Form of the Receptor](https://europepmc.org/articles/PMC6580378/bin/ml-2018-00564f_0007.jpg)
Discovery of Potent and Noncovalent Reversible EGFR Kinase Inhibitors of EGFRL858R/T790M/C797S. - Abstract - Europe PMC